Urinary Excretion of Antimony after Administration of Methyl Glucamine Antimoniate. Preliminary Observations
نویسندگان
چکیده
منابع مشابه
Treatment of Kala-Azar with Methyl Glucamine Antimoniate
a pentavalent antimony compound with the formula Sb.O-H, C7H170-N, containing 28.35 per cent of antimony. The compound makes a stable watery solution and is supplied in ampoules as a 30 per cent solution. Methyl glucamine antimoniate (MGA) is reported to be of a very low toxicity, the m.l.d. being 30 mg. per 20 gm. white mouse or about 1.5 gm. per kilo. It was found to possess curative action i...
متن کاملIn vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate
BACKGROUND Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania infantum. The failures of current treatment with pentavalent antimonials are partially attributable to the emergence of antimony-resistant Leishmania strains. This study analyses the in vitro susceptibility to pentavalent antimony of intracellular amastigotes from a range of L. infantum strains, deri...
متن کاملMonitoring of total antimony and its species by ICP-MS and on-line ion chromatography in biological samples from patients treated for leishmaniasis.
Results from a study are reported in which patients with leishmaniasis were monitored by whole blood, blood plasma, urine, and hair analysis, before, during, and after intramuscular administration of N-methyl meglumine antimoniate. Quadrupole ICP-MS was used for the detection of antimony and on-line ion chromatography for the separation of its species. After typically 30 consecutive daily injec...
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INTRODUCTION: The drugs available for visceral leishmaniasis (VL) treatment in Brazil have specific characteristics in terms of operability, effectiveness, toxicity, and cost. The aim of this study was to estimate the direct costs of therapies recommended by the Ministry of Health (MH) for VL treatment in Brazil. METHODS: The analytical perspective used was that adopted by the Brazilian Publ...
متن کاملEvaluation of Correlation between the In Vitro Susceptibility of Field Isolates of Leishmania major and Clinical Outcomes of Meglumine Antimoniate Therapy in Fars Province, Iran
BACKGROUND This study was designed to detect whether there is a correlation between in vitro susceptibility of field isolates of Leishmania major and the clinical outcomes of meglumine antimoniate (Glucantime®) therapy, the mainstay of cutaneous leishmaniasis treatment in Iran. METHODS Forty-three patients infected with L. major were enrolled in this study from October 2009 to March 2010 and ...
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عنوان ژورنال:
دوره 85 شماره
صفحات -
تاریخ انتشار 1950